Empower Tip: Baseline Noise

In this tip for Empower Chromatography Data System (CDS), we will continue our series on Baseline Noise and learn about Peak-to-Peak noise.

Peak-to-Peak noise measured in a classical sense is simply the highest noise point across the measured region minus the lowest noise point. You can imagine that if this were a gradient chromatogram or if there was significant drift over the measured region, your noise calculation could quite simply equal the drift calculation.

To help eliminate the drift variable from these calculations, it is common to break the noise region into smaller segments. In this example, we have broken the measured noise region into 30-second segments from 26 to 28.3 min.

Now measure Max minus Min noise in each segment and average the resulting noise from each segment.

You can see that we have reduced the measured noise over this region from 1.7 to 1.1 times 10-5 Absorbance Units.

It’s that easy!