System configurations for waters_connect Base Kit with UNIFI 3.0.0

System configurations for waters_connect Base Kit with UNIFI 3.0.0

Introduction

Introduction

This page provides an overview of waters_connect supported system configurations including liquid chromatography (LC) modules, mass spectrometry (MS) instruments, detectors, instrument drivers, Informatics workflows, and applications when you use waters_connect Base Kit with UNIFI 3.0.0 and application add-on kits.

Release Overview

Base Kit

Base Kit

Enables access to core applications for general system use

Application Included

  • waters_connect Platform 220331

Kit Compatibility

  • waters_connect Acquisition Kit 2.2
  • waters_connect CONFIRM Sequence Kit 1.0
  • waters_connect Intact Mass Kit 1.1.1
  • waters_connect Peptide MAM Kit 1.3.1

Application Description

  • waters_connect Platform: For deploying core services. It provides access to the waters_connect HUB and Administration Center applications.
  • waters_connect HUB: Central waters_connect applications access point.
  • Administration Center: For managing the database, managing system users and roles, enabling access to event logging and system-related information, managing system licenses, defining global policies.

Application Included

  • UNIFI 3.0.0

Kit Compatibility

  • waters_connect Acquisition Kit 2.2
  • waters_connect CONFIRM Sequence Kit 1.0
  • waters_connect Intact Mass Kit 1.1.1
  • waters_connect Peptide MAM Kit 1.3.1

Application Description

  • UNIFI: For controlling your LC-MS system to acquire, process, report, qualify and manage generated records as well as import and export data. It provides access to System Console, Qualification and Maintenance, MassLynx Data Capture and Print Capture applications. It supports analytical workflows such as Accurate Mass Screening, Pathway Profiling, Peptide Mapping, Glycan, Intact Protein, Protein Assay, Top Down and Quantify analyses.
  • System Console: For setting up instrument properties, monitoring the system status and performance, performing diagnostic tests, and maintaining the instrument system and its modules.
  • Explorer: For managing records and accessing general properties and information recorded in the audit trail in your deployment.
  • MassLynx Data Capture: Automatically sweeps and imports MassLynx data into the waters_connect deployment.
  • Qualification and Maintenance: Enables verify files, software and instrument system qualification.
  • Print Capture: Creates electronic or hard copy printouts, imports and exports import-captured printouts.

Application Included

  • Laboratory Network Device (LND) 1.10.0

Kit Compatibility

  • waters_connect Acquisition Kit 2.2
  • waters_connect CONFIRM Sequence Kit 1.0
  • waters_connect Intact Mass Kit 1.1.1
  • waters_connect Peptide MAM Kit 1.3.1

Application Description

  • LND: Controls and collects data acquired from connected instrument systems.

Application Included

  • LC-MS Toolkit 1.6.0

Kit Compatibility

  • waters_connect Acquisition Kit 2.2
  • waters_connect CONFIRM Sequence Kit 1.0
  • waters_connect Intact Mass Kit 1.1.1
  • waters_connect Peptide MAM Kit 1.3.1

Application Description

  • LC-MS Toolkit: For data interrogation outside of the defined workflows; provides flexibility to the software that is needed for more advanced use

Application Included

  • ACQUITY UPLC Driver Pack 2021 Release 1 (DP 2021 R1) for waters_connect/UNIFI

Kit Compatibility

  • waters_connect Acquisition Kit 2.2
  • waters_connect CONFIRM Sequence Kit 1.0
  • waters_connect Intact Mass Kit 1.1.1
  • waters_connect Peptide MAM Kit 1.3.1

Application Description

  • ACQUITY UPLC Driver Pack: For LC instrument driver deployment.

Acquisition Kit 2.2

Acquisition Kit 2.2

(compatible with BioAccord only and the LC modules listed in the ACQUITY instrument systems table)


Enables access to acquisition utilities used for biopharma LC-MS workflows such as Intact Mass and Peptide Multi-Attribute Monitoring

Application Included

  • Sample Submission 1.5.0

Application Description

  • Sample Submission: For the management of samples and their submission for analysis on an instrument system.

Kit Compatibility

  • waters_connect Base Kit with UNIFI 3.0.0

Application Included

  • Acquisition Method Editor 2.1.0

Application Description

  • Acquisition Method Editor: For the creation, editing, and management of data acquisition methods.

Kit Compatibility

  • waters_connect Base Kit with UNIFI 3.0.0

Peptide MAM

Peptide MAM

Enables access to the Peptide MAM application for Peptide Multi-Attribute Monitoring

Application Included

  • Peptide MAM 1.3.1

Application Description

  • Peptide MAM: For monitoring of biopharmaceutical product quality attributes (PQA) at the peptide level.

Kit Compatibility

  • waters_connect Base Kit with UNIFI 3.0.0

Intact Mass

Intact Mass

Enables access to the Intact Mass application for biologics Identity and Purity confirmation

Application Included

  • Intact Mass 1.1.1

Application Description

  • Intact Mass: For mass confirmation and purity determination of oligonucleotides, peptides, protein and conjugates.

Kit Compatibility

  • waters_connect Base Kit with UNIFI 3.0.0

CONFIRM Sequence

CONFIRM Sequence

Enables access to the CONFIRM Sequence application for oligonucleotide sequence confirmation

Application Included

  • CONFIRM Sequence 1.0.0

Application Description

  • CONFIRM Sequence: For automated and streamlined oligonucleotide sequence confirmation and impurity characterization workflow

Kit Compatibility

  • waters_connect Base Kit with UNIFI 3.0.0

Configurations

Operating System Support for Workstation Installs

Operating System Support for Workstation Installs

Operating System
Windows

Requirements

  • Windows Defender must be set to Off
  • OS language: English (US)

Versions Supported

  • Windows 10 Enterprise LTSB version 1607
  • Windows 10 Pro version 20H2

Operating System Support for Network Installs

Operating System Support for Network Installs

Operating System
Windows

Versions Supported

Server PC

  • Windows Server 2019 Standard

Requirements

  • Windows Defender must be set to Off
  • OS language: English (US)

LND PC

  • Windows 10 Enterprise LTSB version 1607
  • Windows 10 version 20H2

Requirements

  • OS language: English (US)

Client PC

  • Windows 10 Enterprise LTSB version 1607
  • Windows 10 Pro version 20H2

Requirements

  • OS language: English (US)

System Configurations

System Configurations

Mass Spectrometry Instruments

Mass Spectrometry Instruments

Instrument

  • ACQUITY RDa Mass Detector
    (acquisition control available with base kit)
  • BioAccord LC-MS system
    (acquisition control available with base kit and/or acquisition kit)

waters_connect base kit with UNIFI 3.0.0 and MS instrument DP

  • 3.0.0

Instrument

  • Xevo G2-XS QTof MS
    (acquisition control available with base kit)
  • Vion IMS QTof MS
    (acquisition control available with base kit)

waters_connect base kit with UNIFI 3.0.0 and MS instrument DP

  • 4.1.0

Information in each cell is formatted as follows:

  • n/a = module not supported
  • #.#.# (#.##) = module supported, instrument driver version (firmware version)

Mass Spectrometry Instruments Supported on a Single waters_connect Network Deployment

Mass Spectrometry Instruments Supported on a Single waters_connect Network Deployment

Instrument

Instrument

Instrument

Total Number of Systems

ACQUITY RDa (Tof)

ACQUITY RDa (Tof)

ACQUITY RDa (Tof)

up to 6

BioAccord LC-MS System (Tof)

BioAccord LC-MS System (Tof)

BioAccord LC-MS System (Tof)

up to 6

Xevo G2-XS QTof

Xevo G2-XS QTof

Xevo G2-XS QTof

up to 2

Vion IMS QTof

Vion IMS QTof

Vion IMS QTof

up to 2

Mix of Tof and QTof

Mix of Tof and QTof

Mix of Tof and QTof

up to 4 (up to 2 Tof and up to 2 QTof)

Mix of Tof

Mix of Tof

Mix of Tof

up to 6

Mix of QTof

Mix of QTof

Mix of QTof

up to 2

Notes:

  • BSM has updated firmware to support new PCBs.
  • #.#.# (#.##) = module supported, instrument driver version (firmware version)
  • n/a = module not supported

Supporting Files

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