waters_connect 3.7.0 Release Overview

waters_connect Base Kit comprises of platform Services, utility tools and core applications such as Hub, Administration, Scientific Library for general system use.

Key benefits in this kit include:

• Enhanced compliance readiness through improved administrative access controls using global policies and role definitions, including:

  • Ensuring consistent date and time stamps across all applications via a new date and time policy;
  • Differentiating between Customer and Waters Administration roles;
  • Password-controlled mechanism for resetting administrator accounts;
• Increased compliance readiness with more comprehensive insights in the audit trail including:
  • extended traceability for records associated to the raw data set;
  • view simple or detailed history of records , including the ability to restore previous versions;
  • controlled generation of analysis copies within the MS Quan application;
  • full audit trail and control for user and system actions during data acquisitions;
  • Record of key actions within the application, such as tracking the number of times re-processing is performed.
  • Quick and easy access to targeted system audit trail information, reducing time spent on administrative tasks.
  • Rich information on imported data records, including “created date,” “last update date,” “created by,” “last updated by,” “restore date,” and “restored by” fields.
• Increased compliance readiness with more efficient records handling in draft states and better control policies over signature methods and active multi-user sessions, such as:
  • new global policies to control and record actions in the audit trail when closing records in a draft state, whether discarding or saving changes;
  • view read-only records generated by other users in edit state, with the option to take ownership of those records in draft state.

• Enhanced compliance readiness through a richer reporting and e-signature workflow, including:

  • Displaying the electronic signature status directly within waters_connect application reports;
  • Permission-controlled editing and customization of application reports and definition of e-signature sequences;
  • clear and traceable history of records for generated reports, linked to report templates and analyses.
• Improved awareness of storage space capacity for efficient product use and performance with a standalone tool that allows viewing of space usage across all waters_connect install types.
• Reduced product installation times for clean waters_connect workstation installs within an automated software deployment mechanism that chains the installation of core services, applications, and instrument drivers.

waters_connect Acquisition Kit comprises of Sample Submission, Method Editor and Laboratory Network Device applications. This kit enables data acquisition with Waters instrument systems used with waters_connect Quantitative analysis software, such as Xevo TQ-S cronos, Xevo TQ-S micro, Xevo TQ-XS and Xevo TQ Absolute, and/or accurate mass applications with Xevo G2-XS QTof, Xevo G3 QTof, Xevo MRT, BioAccord LC-MS System and ACQUITY RDa detector.

Key benefits in this kit include:

• Improved productivity when submitting samples with Xevo Tandem Quadrupole instruments by enabling a fast polarity switch of 4 ms in the method editor application.

waters_connect LC-MS Toolkit enables data interrogation outside of the defined workflows and provides flexibility to the software that is needed for more advanced use.

Key benefits in this application include:

• Increased data clarity and speed to results with data view and interrogation enhancements in the LC-MS Toolkit application, such as:
  • automatic calculation and annotation for the mass resolution of an ion;
  • base peak mass annotations in chromatograms;
  • view and interrogate Xevo MRT data;
  • perform multiple extracted ion chromatograms from pre-saved groups of analytes;
• Increased productivity by generating LC-MS Toolkit sessions in real time and post acquisition at the sample list level from within the submission application.

waters_connect Data Convert enables increased data compatibility with third-party software applications via conversion of MS, MS/MS, DDA and MSE data into .mzML format.

Key benefits in this application include:

• Improved productivity when submitting samples with Xevo MRT, Xevo G3 QTof, Xevo G2-XS QTof and ACQUITY RDa by converting acquired data to generic file format (.mzML) in real-time, ensuring immediate availability for third-party software use

waters_connect MS Quan is a quantitative analysis software available on our core Xevo tandem quadrupole family of mass spectrometers. It enables routine small-molecule quantitation and accelerates quantitation data processing and review steps with exception-focused review and easy-to-view chromatogram windows for multiple samples.

Key benefits in this application include:

Expanding MS Quan application capabilities with focus on impurity processing & customer feedback, including:

• Optical data processing (TUV & PDA)
• Recovery calculations
• Relative standard error
• Lock data on signing reports
• Per injection reports including overlays
• Simple exceptions in report tables

waters_connect UNIFI enables the execution of accurate mass experiments ranging from Small Molecules to Biologics. Moreover, it provides access to core applications such as System Console, Device Management, Explorer, and Qualification for general system use.

Key benefits in this application include:

• Quality improvements and critical anomaly resolution

waters_connect Peptide Multi-Attribute Method (MAM) enables monitoring of biopharmaceutical product quality attributes (PQA) at the peptide level.

Key benefits in this application include:

• An Application Programming Interface (API) is now available that supports creation of analyses and retrieval of results by third party informatics tools;

• Enhanced processing of data containing higher mass peptides by an Improved Monoisotopic Peak Detection (IMPD) routine, which supports detection of a lower intensity or missing monoisotopic peak;

• Localization into Japanese.

waters_connect Intact Mass enables biologics mass confirmation and purity determination of oligonucleotides, peptides, protein and conjugates.

Key benefits in this application include:

• Support for PDA optical detectors. In addition to TUV, users can now view the MaxPlot optical channel from the PDA detector, and use this channel for detection. If the injection contains PDA data, the MaxPlot chromatogram is displayed and used for peak detection. If the MaxPlot chromatogram is missing, the first optical chromatogram in the injection is displayed and used for peak detection;

• Support for Sample Organizer and Sample Manager vials, allowing up to19 microtiter plates, or, 9 intermediate height plates (or 2-mL vial holders), or, 6 deep-well plates (or 4-mL vial holders). Increasing the potential throughput for Intact Mass users.

• Optical-only workflows with built in IEX, SEC and reverse-phase column support and analysis expand the utility of Intact Mass to groups within the laboratory without MS requirements;

• Automatic sample report generation further supports a high-throughput Intact Mass workflow. Users do not need to open complete analyses to download individual reports. They now have the option to download reports to a local folder automatically upon completion of processing, and also the option of a high-throughput report template designed to deliver the important details from a large amount of data in an efficient manner;

• Grouped calculations allow streamlined IEX, SEC and reverse-phase analysis using MS data;

• Processing of analyses can now be cancelled, preventing loss of time and resources processing analyses with known issues.

waters_connect CONFIRM Sequence enables streamlined oligonucleotide sequence confirmation and impurity characterization workflow.

Key benefits in this application include:

• The user can now confirm if their chosen nucleic acid digestion strategies can theoretically produce the desired sequence coverage, using a visualization of theoretical digest sequence coverage, including calling out segments of isobaric mass ambiguity. This helps users to determine the best digestion strategy to achieve optimal sequence coverage using unique digestion products;

• Localization into Japanese.

waters_connect Map Sequenceenables accurate mass mapping of digested oligonucleotides.

Key benefits in this application include:

• Input of in silico predicted digestion products
• Processing of pre-acquired data to identify digestion products
• Grouped results for rapid assessment of sequence coverage
• Identification of structural isomers and sequence repeats
• Output of results for coverage map review

   

Quantitative analysis software available on our core Xevo tandem quadrupole family of mass spectrometers to enable laboratories to process large sample batches quickly and easily, significantly reducing the time spent on data review. Maximize your productivity with a compliant-ready workflow for analytical methodologies ranging from PFAS to genotoxic impurity analysis.

Biopharmaceutical accurate mass applications for protein-based therapeutics, vaccines, and nucleic acid-based therapeutics.

Bioprocess accurate mass applications for process (spent cell culture media) and product quality attribute monitoring including the Bioprocess Walk-Up Solution.

Accurate mass-based solutions for screening of small molecules with versatile qualitative and quantitative analysis of compounds like pesticides, drugs of abuse, metabolites, impurities, extractables, and leachables.

Accurate mass-based metabolomics, lipidomics and metabolite identification solutions with integration with 3rd Party software (via .mzML and/or via API).

Operating System
Windows

Requirements

• Windows Defender must be set to Off
• OS language: English (US), Japanese (Japan)
• Windows images provided with waters_connect PCs include Windows IoT Enterprise licensing which enables extended support on the operating system end of service over the standard edition. View more information on Windows releases.

Versions Supported
Workstation PC

• Windows 10 Enterprise LTSC 2021 edition (version 21H2)
• Windows 10 Enterprise IoT LTSC 2021 edition (version 21H2)
• Windows 10 Pro version 22H2

Operating System
Windows

Requirements

• Windows Defender must be set to Off (Server PCs)
• OS language: English (US), Japanese (Japan)
  • Note: for Client PCs only the software deployment is supported on European and Japanese language versions of Windows. However, Hub is displayed in English (US) or Japanese (Japan) only.
• Windows images provided with waters_connect PCs include Windows IoT Enterprise licensing which enables extended support on the operating system end of service over the standard edition. View more information on Windows releases.

Versions Supported