waters_connect 4.0.0 LTS Release Overview

waters_connect Base Kit comprises of platform Services, utility tools and core applications such as Hub, Administration, Scientific Library for general system use.

Key benefits in this kit include:

• Enhanced lab operational security through the following measures:

  • Implementation of anti-tampering mechanisms for installed binaries using Verify Files.
  • Update to the latest third-party components used in waters_connect platform services.
  • Replacement of the deprecated DES algorithm.
  • Ability to operate waters_connect with Windows Defender enabled
  • Support for Windows 11 Pro and LTSC 2024 versions for Client PCs in a waters_connect network deployment.
• Increase lab operational efficiency by enabling a more scalable network of users with the capacity to activate up to 100 users for waters_connect network installs, including the ability to monitor active user sessions.
• Enhanced understanding of data storage capacity through a traffic light indicator and maintenance recommendation tooltips in the waters_connect HUB for optimized product use and performance.

• Enhanced customer experience with user interface improvements in the waters_connect HUB, including the ability to fit and display more application icons and an at-a-glance view of the waters_connect product version.

• Improved waters_connect Application Programming Interface (API) data streaming performance to accelerate workflow application data generation for ion chromatograms and data-dependent acquisition switch tables.

• Improved product quality and stability by addressing high impact software anomalies such as:

  • Slow generation of verify files and IQ reports.
  • Data buffering issues when changing location and method location on used sample list in sample submission.
  • Performance degradation with analysis methods containing signature methods.
  • Hanging state of other sample lists when using the 'Abort all' option.
  • Corruption of PDF exports for large reports.
  • Inconsistent LND restart in the Device Management application.

waters_connect Acquisition Kit comprises of Sample Submission, Method Editor and Laboratory Network Device applications. This kit enables data acquisition with Waters instrument systems used with waters_connect Quantitative analysis software, such as Xevo TQ-S cronos, Xevo TQ-S micro, Xevo TQ-XS and Xevo TQ Absolute, and/or accurate mass applications with Xevo G2-XS QTof, Xevo G3 QTof, Xevo MRT, BioAccord LC-MS System and ACQUITY RDa detector.

Key benefits in this kit include:

• Expanded capabilities of your instrument systems inlets and sources with support for GC-HRMS workflow using the Xevo G3 QTof, now compatible with:

  • Agilent 8890 GC system.
  • Agilent 7693A Automatic Liquid Sampler system.
  • CTC PAL3 Series 2 Autosampler system.
  • Waters Atmospheric Pressure Gas Chromatography (APGC) source.
  • waters_connect sample submission for acquisition and UNIFI for data processing, in workstation deployment.

   

waters_connect LC-MS Toolkit enables data interrogation outside of the defined workflows and provides flexibility to the software that is needed for more advanced use.

Key benefits in this kit include:

• Increased data clarity and speed to results with data view and interrogation enhancements in the LC-MS Toolkit application, such as:
  • Manual integration of a chromatogram.
  • Performance improvements for XIC and DDA switch table generation.
  • Improved advanced extract tool.

waters_connect Data Convert enables increased data compatibility with third-party software applications via conversion of MS, MS/MS, DDA and MSE data into .mzML format.

Key benefits in this application include:

• Improved data clarity and usability when converting data to generic file format (.mzML) with enhancements in the Data Convert application, including:
  • Component detection (peak picking, isotope deconvolution and, where appropriate, CCS calculation), excluding when acquire & export is used with ACQUITY RDa.
  • Advanced user settings for arguments definition.
  • Storage space capacity notifications.

waters_connect MS Quan is a quantitative analysis software available on our core Xevo tandem quadrupole family of mass spectrometers. It enables routine small-molecule quantitation and accelerates quantitation data processing and review steps with exception-focused review and easy-to-view chromatogram windows for multiple samples.

Key benefits in this application include:

• Expanding MS Quan application capabilities with focus on impurity processing, including:
  • Optical data processing (TUV & PDA).
  • Recovery calculations.
  • Relative standard error.
  • Lock data on signing reports.
  • Per-injection reports including overlays.
  • Simple exceptions in report tables.

waters_connect UNIFI enables the execution of accurate mass experiments ranging from Small Molecules to Biologics. Moreover, it provides access to core applications such as System Console, Device Management, Explorer, and Qualification for general system use.

Key benefits in this application include:

• Achieve quicker decisions using UNIFI Accurate Mass workflows by reducing the time needed for generating reports and opening analysis methods that incorporate electronic signature methods.
• Improved data clarity when importing MassLynx data by including more information in imported sample lists and sample sets with new fields such as subject, submitter, MassLynx user and sample dilution.

The waters_connect Pattern Analysis application increases data clarity in complex assays and enhances the confidence in identifying contaminants, such as polymers, PFAS and PCBs.

Key benefits in this application include:

• Leverage the unique mass spectral properties of chemicals to resolve them from matrix background.
• Data review workflow with interactive plots to aid in compound classification.
• Confidence in identifying emerging exogenous contaminants.
• Development of a comprehensive library for targeted comparison.

waters_connect Peptide Multi-Attribute Method (MAM) enables monitoring of biopharmaceutical product quality attributes (PQA) at the peptide level.

Key benefits in this application include:

• Support for PDA optical detectors. In addition to TUV, users can now view the optical channels from the PDA detector.
• Support for Sample Organizer, allowing up to19 microtiter plates, or, 9 intermediate height plates, or, 6 deep-well plates. Increasing the potential throughput for Peptide MAM users.

waters_connect Intact Mass enables biologics mass confirmation and purity determination of oligonucleotides, peptides, protein and conjugates.

Key benefits in this application include:

• Support for PDA optical detectors. In addition to TUV, users can now view the MaxPlot optical channel from the PDA detector, and use this channel for detection. If the injection contains PDA data, the MaxPlot chromatogram is displayed and used for peak detection. If the MaxPlot chromatogram is missing, the first optical chromatogram in the injection is displayed and used for peak detection.
• Support for Sample Organizer and Sample Manager vials, allowing up to19 microtiter plates, or, 9 intermediate height plates (or 2-mL vial holders), or, 6 deep-well plates (or 4-mL vial holders). Increasing the potential throughput for Intact Mass users.
• Optical-only workflows with built in IEX, SEC and reverse-phase column support and analysis expand the utility of Intact Mass to groups within the laboratory without MS requirements.
• Automatic sample report generation further supports a high-throughput Intact Mass workflow. Users do not need to open complete analyses to download individual reports. They now have the option to download reports to a local folder automatically upon completion of processing, and also the option of a high-throughput report template designed to deliver the important details from a large amount of data in an efficient manner.
• Grouped calculations allow streamlined IEX, SEC and reverse-phase analysis using MS data.
• Processing of analyses can now be cancelled, preventing loss of time and resources processing analyses with known issues.

waters_connect CONFIRM Sequence enables streamlined oligonucleotide sequence confirmation and impurity characterization workflow.

Key benefits in this application include:

• The user can now confirm if their chosen nucleic acid digestion strategies can theoretically produce the desired sequence coverage, using a visualization of theoretical digest sequence coverage, including calling out segments of isobaric mass ambiguity. This helps users to determine the best digestion strategy to achieve optimal sequence coverage using unique digestion products;
• Localization into Japanese.

waters_connect Map Sequence enables accurate mass mapping of digested oligonucleotides.

Key benefits in this application include:

• Input of in silico predicted digestion products.
• Processing of pre-acquired data to identify digestion products.
• Grouped results for rapid assessment of sequence coverage.
• Identification of structural isomers and sequence repeats.
• Output of results for coverage map review.

The waters_connect Bioprocess Monitor application enables routine, in-process monitoring of spent media components and product titer via absolute and relative quantification using LC/UV, LC/MS & LC-UV/MS techniques.

Key benefits in this application include:

• Near-real time quantitative results for in-process samples with a streamlined sample analysis workflow and automated processing.
• Straight to the answer you need with a simplified results review.
• Confidence in the data with robust data processing and ability to review by exception.
• Statistical evaluation of the data with connectivity with third-party software JMP.
• Bioprocess Walk-Up Solutions and Sartorius Ambr data interface.

Quantitative analysis software available on our core Xevo tandem quadrupole family of mass spectrometers, enabling laboratories to process large sample batches quickly and easily, significantly reducing the time spent on data review. Maximize your productivity with a compliant-ready workflow for analytical methodologies ranging from PFAS to genotoxic impurity analysis.

Biopharmaceutical accurate mass applications for protein-based therapeutics, vaccines, and nucleic acid-based therapeutics.

Bioprocess accurate mass applications for process (spent cell culture media and product titer) and product quality attribute monitoring including the Bioprocess Walk-Up Solution.

Accurate mass-based solutions for targeted and non-targeted screening of small molecules, offering versatile qualitative and quantitative analysis of compounds such as pesticides, drugs of abuse, metabolites, impurities, extractables and leachables, and identification of contaminants like polymers, PFAS, and PCBs in complex samples.

Accurate mass-based metabolomics, lipidomics and metabolite identification solutions with integration with 3rd Party software (via .mzML and/or via API).

Operating System
Windows

Requirements

• OS language: English (US), Japanese (Japan).
• Windows images provided with waters_connect PCs include Windows IoT Enterprise licensing which enables extended support on the operating system end of service over the standard edition. View more information on Windows releases.

Versions Supported
Workstation PC

• Windows 10 Enterprise LTSC 2021 edition (version 21H2)
• Windows 10 Enterprise IoT LTSC 2021 edition (version 21H2)
• Windows 10 Pro version 22H2

Operating System
Windows

Requirements

• OS language: English (US), Japanese (Japan)
  • Note: for Client PCs only the software deployment is supported on European and Japanese language versions of Windows.  However, Hub is displayed in English (US) or Japanese (Japan) only.
• Windows images provided with waters_connect PCs include Windows IoT Enterprise licensing which enables extended support on the operating system end of service over the standard edition. View more information on Windows releases.

Versions Supported