MassLynx Software Releases Overview​

MassLynx Software Releases Overview​

Introduction

Introduction

This page provides an overview of MassLynx Software releases along with the release key benefits, recommended use, and associated level of software support.

For more information on software versions or upgrading your software, please contact your local Waters representative.

 


MassLynx SCN 1050

MassLynx SCN 1050

Type

Incremental Release​

Release Date

June 2025

Status

Mainstream support

Release Overview

MassLynx 4.2 SCN 1050

Recommended Use

For customers who need to acquire, process, analyze, manage, and share nominal and exact mass data--MassLynx Software supports workflows across Waters mass spectrometry systems.

Key Benefits

  • Enhanced lab operational security with support for Windows 11​

  • Support for Xevo TQ Absolute XR Mass Spectrometer​

  • Support for Evosep LC instruments

Supported Windows Version

  • Windows 11 Enterprise LTSC 2024 (64-bit) [Waters Lenovo P5 6 Core only]​

  • Windows 10 Enterprise LTSC 2021 (64-bit) [Waters Lenovo P5 6 core, P5 12 Core and P520 only]​

  • Windows 10 Enterprise LTSB 1607

Supported Instruments

  • ACQUITY QDa ​Mass Detector
  • ACQUITY QDa II ​Mass Detector

  • RADIAN ASAP ​Mass Detector

  • SQ Detector 2 ​

  • SYNAPT XS ​MS

  • Xevo G2 XS QTof ​MS

  • Xevo G3 QTof ​MS

  • Xevo TQ Absolute XR​ MS

  • Xevo TQ Absolute ​MS

  • Xevo TQD ​MS

  • Xevo TQ-GC ​MS

  • Xevo TQ-S ​MS

  • Xevo TQ-S cronos MS ​

  • Xevo TQ-S micro ​MS

  • Xevo TQ-XS MS


MassLynx SCN 1049

MassLynx SCN 1049

Type

Incremental Release

Release Date

October 2024

Status

Sustaining support & superseded by SCN 1050​

Release Overview

MassLynx 4.2 SCN 1049

Recommended Use

For customers who need to acquire, process, analyze, manage, and share nominal and exact mass data--MassLynx Software supports workflows across Waters mass spectrometry systems.

Key Benefits

  • Support for the ionKey source with the Xevo TQ Absolute MS system​

  • Support for the new Lenovo P5 6 core computers on Windows 10 LTSC 2021 ​

  • Faster polarity switching for Xevo TQ Absolute MS and Xevo TQ-XS MS systems

Supported Windows Version

  • Windows 10 Enterprise LTSC 2021 (64-bit), [Waters Lenovo P520 only]

  • Windows 10 Enterprise LTSB 1607

Supported Instruments

  • ACQUITY QDa II ​Mass Detector

  • ACQUITY QDa ​Mass Detector

  • RADIAN ASAP ​Mass Detector

  • SQ Detector 2 ​

  • Xevo TQ Absolute ​MS

  • Xevo TQD ​MS

  • Xevo TQ-GC ​MS

  • Xevo TQ-S ​MS

  • Xevo TQ-S cronos MS ​

  • Xevo TQ-S micro ​MS

  • Xevo TQ-XS MS


MassLynx SCN 1048

MassLynx SCN 1048

Type

Incremental Release

Release Date

July 2024

Status

Sustaining support & superseded by SCN 1049

Release Overview

MassLynx 4.2 SCN 1048

Recommended Use

For customers who need to acquire, process, analyze, manage, and share nominal and exact mass data--MassLynx Software supports workflows across Waters mass spectrometry systems.

Key Benefits

  • ACQUITY QDA II Mass Detector support ​

  • Improved purification workflow and improved stability for FractionLynx​ Software

  • CTC PAL3 support for open access ​providing our customers with high sample capacity, for open access/walk-up solutions​​

  • Major improvements to sample plate visualization, automatic method sorting and remote system monitor​

  • MassLynx Basic Security support on a Xevo TQ Absolute MS system connected with DESI XS HTL source

Supported Windows Version

  • Windows 10 Enterprise LTSC 2021 (64-bit), [Waters Lenovo P5 6 Core and P520 only]

  • Windows 10 Enterprise LTSB 1607

Supported Instruments

  • ACQUITY QDa ​Mass Detector

  • ACQUITY QDa II ​Mass Detector

  • RADIAN ASAP ​Mass Detector

  • SQ Detector 2 ​

  • Xevo TQ Absolute ​MS

  • Xevo TQD ​MS

  • Xevo TQ-GC ​MS

  • Xevo TQ-S ​MS

  • Xevo TQ-S cronos MS ​

  • Xevo TQ-S micro ​MS

  • Xevo TQ-XS MS


MassLynx SCN 1046

MassLynx SCN 1046

Type

Incremental Release

Release Date

March 2024

Status

Sustaining support & superseded by SCN 1048

Release Overview

MassLynx 4.2 SCN 1046

Recommended Use

For customers who need to acquire, process, analyze, manage, and share nominal and exact mass data--MassLynx Software supports workflows across Waters mass spectrometry systems.

Key Benefits

  • Improved purification workflow and improved stability for FractionLynx​ Software

  • Mass directed fraction collection with SQ Detector 2 when using a WFM-A fraction collector

  • Open access enhancements

Supported Windows Version

  • Windows 10 Enterprise LTSC 2021 (64-bit), [Waters Lenovo P520 only]

  • Windows 10 Enterprise LTSB 1607​

Supported Instruments

  • ACQUITY QDa ​Mass Detector

  • RADIAN ASAP ​Mass Detector

  • SQ Detector 2 ​

  • Xevo TQ Absolute ​MS

  • Xevo TQD ​MS

  • Xevo TQ-GC ​MS

  • Xevo TQ-S ​MS

  • Xevo TQ-S cronos ​MS

  • Xevo TQ-S micro ​MS

  • Xevo TQ-XS MS

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