waters_connect 3.6.0 Release Overview

Comprises platform components and core applications such as Hub, Administration, System Console, Device Management, Explorer, Qualification for general system use.

Key benefits in this release include:

• waters_connect Base Kit comprises of platform services, utility tools and core applications such as Hub, Administration, Scientific Library for general system use

• Improved lab automation and integration with 3rd party software via new endpoints in the waters_connect Application Programming Interface (API). Benefit from a greater API connectivity and performance such as:
  • access to lock mass corrected data, continuum spectra, centroided spectra, combined spectra, extracted mass chromatograms;
  • direct data transfer to Mass Analytica software suite for data generated in waters_connect with instruments such as Xevo G3 QTof and Xevo MRT;
  • build workflows around method draft lifecycles;
  • search common fields for Name, Description, Version, CreatedDateTime, ModifiedDateTime, Folder, TypeId,  CreatedByUsername,  ModifiedByUsername, State;
  • get information about the backup jobs;
  • support registered third party browser apps previously blocked by the browser CORS setting.

LC-MS Toolkit enables data interrogation outside of the defined workflows and provides flexibility to the software that is needed for more advanced use.

Key benefits in this release include:

• Increased data clarity and speed to results with data view and interrogation enhancements in the LC-MS Toolkit application, such as:
  • automatic calculation and annotation for the mass resolution of an ion;
  • base peak mass annotations in chromatograms;
  • view and interrogate Xevo MRT data;
  • perform multiple extracted ion chromatograms from pre-saved groups of analytes;
• Increased productivity by generating LC-MS Toolkit sessions in real time and post acquisition at the sample list level from within the submission application.

waters_connect Acquisition Kit comprises of Sample Submission, Method Editor and Laboratory Network Device enable data acquisition with Waters instrument systems used for accurate mass applications with Xevo G2-XS QTof, Xevo G3 QTof, Xevo MRT and BioAccord System.

Key benefits in this release include:

• Increased lab productivity and throughput with the introduction of support for the Xevo MRT instrument within the Sample Submission and Method Editor applications in a waters_connect workstation install;
• Improved productivity and usability at the point of sample submission with the ability to select injections in the sample list and directly interrogate data in LC-MS Toolkit sessions from either injections being acquired, and from samples acquired completed.

waters_connect Data Convert enables increased data compatibility with third-party software applications via conversion of MS, MS/MS, DDA and MSE data into .mzML format.

Key benefits in this release include:

• Improved productivity when submitting samples with Xevo MRT, Xevo G2-XS QTof and ACQUITY RDa by converting acquired data to generic file format (.mzML) in real-time, ensuring immediate availability for third-party software use.

waters_connect UNIFI enables the execution of accurate mass experiments ranging from Small Molecules to Biologics. Moreover, it provides access to core applications such as System Console, Device Management, Explorer, and Qualification for general system use.

Key benefits in this release include:

• Increased usability and productivity for the Small Molecules and Biologics workflows by automating data acquisition in sample submission and data processing in UNIFI when using Xevo MRT, Xevo G3 QTof, Xevo G2-XS QTof, and ACQUITY RDa;
• Faster time to results and enhanced data clarity when using the UNIFI application workflows with Xevo MRT instrument. Benefit from the high mass resolving power and sub-ppm mass accuracy even at the fastest acquisition rates and leverage the power of confident identification of analytes across a range of samples and matrices with the UNIFI Small Molecules and UNIFI Biologics workflows;
• Increased lab productivity with the introduction of support on waters_connect short term releases for Vion IMS QTof instrument within the UNIFI application for workstation and network installs.

The Peptide Multi-Attribute Method (MAM) application enables monitoring of biopharmaceutical product quality attributes (PQA) at the peptide level.

Key benefits in Peptide MAM 1.8.0 release include:

• An Application Programming Interface (API) is now available that supports creation of analyses and retrieval of results by third party informatics tools.
• Enhanced processing of data containing higher mass peptides by an Improved Monoisotopic Peak Detection (IMPD) routine, which supports detection of a lower intensity or missing monoisotopic peak.
• Localization into Japanese

Key benefits in Peptide MAM 1.8.1 release include:

• Support for PDA optical detectors. In addition to TUV, users can now view the optical channels from the PDA detector.
• Support for Sample Organizer, allowing up to19 microtiter plates, or, 9 intermediate height plates, or, 6 deep-well plates. Increasing the potential throughput for Peptide MAM users.

Intact Mass enables biologics mass confirmation and purity determination of oligonucleotides, peptides, protein and conjugates.

Key benefits in this release include:

• Support for PDA optical detectors. In addition to TUV, users can now view the MaxPlot optical channel from the PDA detector, and use this channel for detection. If the injection contains PDA data, the MaxPlot chromatogram is displayed and used for peak detection. If the MaxPlot chromatogram is missing, the first optical chromatogram in the injection is displayed and used for peak detection. 
• Support for Sample Organizer and Sample Manager vials, allowing up to19 microtiter plates, or, 9 intermediate height plates (or 2-mL vial holders), or, 6 deep-well plates (or 4-mL vial holders). Increasing the potential throughput for Intact Mass users.
• Optical-only workflows with built in IEX, SEC and reverse-phase column support and analysis expand the utility of Intact Mass to groups within the laboratory without MS requirements. 
• Automatic sample report generation further supports a high-throughput Intact Mass workflow. Users do not need to open complete analyses to download individual reports. They now have the option to download reports to a local folder automatically upon completion of processing, and also the option of a high-throughput report template designed to deliver the important details from a large amount of data in an efficient manner.
• Grouped calculations allow streamlined IEX, SEC and reverse-phase analysis using MS data.
• Processing of analyses can now be cancelled, preventing loss of time and resources processing analyses with known issues.

The CONFIRM Sequence application enables streamlined oligonucleotide sequence confirmation and impurity characterization workflow

Key benefits in this release include:

• The user can now confirm if their chosen nucleic acid digestion strategies can theoretically produce the desired sequence coverage, using a visualization of theoretical digest sequence coverage, including calling out segments of isobaric mass ambiguity. This helps users to determine the best digestion strategy to achieve optimal sequence coverage using unique digestion products.
• Localization into Japanese

waters_connect Map Sequence enables accurate mass mapping of digested oligonucleotides.

Key benefits in this application include:

• Input of in silico predicted digestion products
• Processing of pre-acquired data to identify digestion products
• Grouped results for rapid assessment of sequence coverage
• Identification of structural isomers and sequence repeats
• Output of results for coverage map review

Quantitative analysis with tandem quadrupole mass spectrometry systems

• Not supported in this release. Please refer to the waters_connect 3.2.0 LTS and waters_connect 3.3.0 pages for more information.

Biopharmaceutical accurate mass applications for protein-based therapeutics, vaccines, and nucleic acid-based therapeutics.

Bioprocess accurate mass applications for process (spent cell culture media) and product quality attribute monitoring including the Bioprocess Walk-Up Solution.

Accurate mass-based solutions for screening of small molecules with versatile qualitative and quantitative analysis of compounds like pesticides, drugs of abuse, metabolites, impurities, extractables, and leachables.

Accurate mass-based metabolomics, lipidomics and metabolite identification.

Operating System
Windows

Requirements

• Windows Defender must be set to Off
• OS language: English (US), Japanese (Japan).
• Windows images provided with waters_connect PCs include Windows IoT Enterprise licensing which enables extended support on the operating system end of service over the standard edition. View more information on Windows releases.

Versions Supported

Workstation PC

• Windows 10 Enterprise LTSC 2021 edition (version 21H2)
• Windows 10 Enterprise IoT LTSC 2021 edition (version 21H2)*
• Windows 10 Pro version 22H2

Operating System
Windows

Requirements

• Windows Defender must be set to Off
• Server and LND OS language: English (US), Japanese (Japan) (Server and LND).
• Client OS language: Deployment possible on European and Japanese language versions of Windows. Hub is displayed in English (US) or Japanese (Japan) only.
• Windows images provided with waters_connect PCs include Windows IoT Enterprise licensing which enables extended support on the operating system end of service over the standard edition. View more information on Windows releases.

Versions Supported