waters_connect Releases Overview

Recommended Use

For customers who:

• require a secure and robust solution for a long period of time as frequent upgrades & re-validations have a high cost for their laboratory. 
• run the following workflows:
  • waters_connect for Quantitation | Quantitative analysis software available on our core Xevo tandem quadrupole family of mass spectrometers, enabling laboratories to process large sample batches quickly and easily, significantly reducing the time spent on data review. Maximize your productivity with a compliant-ready workflow for analytical methodologies ranging from PFAS to genotoxic impurity analysis.
  • waters_connect for Biopharma | Accurate mass applications for protein-based therapeutics, vaccines, and nucleic acid-based therapeutics including applications for bioprocessing (spent cell culture media and product titer) and product quality attribute monitoring.
  • waters_connect for Small Molecules | Accurate mass-based solutions for targeted and non-targeted screening of small molecules, offering versatile qualitative and quantitative analysis of compounds such as pesticides, drugs of abuse, metabolites, impurities, extractables and leachables, and identification of contaminants like polymers, PFAS, and PCBs in complex samples.
  • waters_connect for Research & Routine | Accurate mass-based metabolomics, lipidomics and metabolite identification solutions with integration with third-party software (via .mzML and/or via API).

Key Benefits

• Enhanced lab operational security through anti-tampering mechanisms, use of Windows Defender and support for Windows 11 Pro and LTSC 2024 versions for Client PCs in a waters_connect network deployment.

• Reduced time required for generating reports and opening analysis methods that incorporate electronic signature methods within in the UNIFI Accurate Mass workflows.

• Expanded capabilities of your instrument systems inlets and sources with support for Gas Chromatography assays for waters_connect accurate mass workflow using the Xevo G3 QTof.

• Enhanced customer experience with user interface improvements in the waters_connect HUB, including the ability to display more applications and an at-a-glance view of the waters_connect product version.

• Improved waters_connect API data streaming performance to accelerate workflow application data generation for ion chromatograms and data-dependent acquisition switch tables.

• Enhanced understanding of data storage capacity through a traffic light indicator and maintenance recommendation tooltips in the waters_connect HUB for optimized product use and performance.

• Improved data clarity when importing MassLynx data by including more information in imported sample lists and sample sets with new fields such as subject, submitter, MassLynx user and sample dilution.

• Increased lab operational efficiency by enabling a more scalable network of users with the capacity to activate up to 100 users for waters_connect network installs.

• Increased data clarity and speed to results with manual integration of chromatograms and performance improvements for XIC and DDA switch table generation in the LC-MS Toolkit application.

• Improved data clarity and usability when converting data to .mzML with component detection, advanced user settings and storage space capacity notifications in the Data Convert application.

• Expanded quantitation workflow capabilities with new application features focused on impurity processing, including optical data processing, recovery calculation and relative standard errors.

• Expanded biopharma workflow capabilities with Bioprocess Monitor, a new waters_connect application that enables routine, in-process monitoring of spent media components and product titer via absolute and relative quantification using LC/UV, LC/MS & LC-UV/MS techniques.

• Expanded small molecule workflow capabilities with Pattern Analysis, a new waters_connect application that enhances confidence in identifying contaminants such as polymers, PFAS, and PCBs in complex samples.
  
  Note: full information on new features and quality improvements available in the release notes

Recommended Use

For customers who:

• want to stay at the forefront of innovation and are comfortable with routinely updating the software to access the latest features and quality improvements;

For customers running the following workflows:

• waters_connect for Quantitation — Quantitative analysis software available on our core Xevo tandem quadrupole family of mass spectrometers to enable laboratories to process large sample batches quickly and easily, significantly reducing the time spent on data review. Maximize your productivity with a compliant-ready workflow for analytical methodologies ranging from PFAS to genotoxic impurity analysis.
• waters_connect for Biopharma — Accurate mass applications for protein-based therapeutics, vaccines, and nucleic acid-based therapeutics including applications for bioprocessing (spent cell culture media) and product quality attribute monitoring.
• waters_connect for Small Molecules — Accurate mass-based solutions for screening of small molecules with versatile qualitative and quantitative analysis of compounds like pesticides, drugs of abuse, metabolites, impurities, extractables, and leachables.
• waters_connect for Research & Routine — Accurate mass-based metabolomics, lipidomics and metabolite identification solutions with integration with 3rd Party software (via .mzML and/or via API)

Key Benefits

• Enhanced compliance readiness through improved administrative access controls using date and time stamp global policies and flexible Admin role definitions;
• Increased compliance readiness with more comprehensive insights in the audit trail for imported data, system and event logs, acquisition events, methods and MS Quan results sets;
• Increased compliance readiness with more efficient records handling in draft states and better control policies over signature methods;
• Enhanced compliance readiness through traceable history of information for generated reports with MS Quan and more permission controlled  e-signature workflow,
• Improved productivity when submitting samples with Xevo Tandem Quadrupole instruments by enabling a fast polarity switch of 4ms in the method editor application.
• Improved awareness on storage space capacity for efficient product use and performance with a standalone tool that allows viewing of space usage for all waters_connect install types.
• Reduced product installation times for clean waters_connect workstation installs within an automated software deployment mechanism that chains the installation of core services, applications, and instrument drivers;
• Expanded Quantitation workflow capabilities with new application features to accelerate time to results with focus Genotoxic impurity processing; 
• Expanded Biopharma workflow capabilities with MAP Sequence, a new waters_connect application that enables accurate mass mapping of digested oligonucleotides.

Note: full information on new features and quality improvements available in the release notes

Recommended Use

For customers who: 

• want to stay at the forefront of innovation and are comfortable with routinely updating the software to access the latest features and quality improvements

For customers running the following workflows:

• waters_connect for Biopharma — Accurate mass applications for protein-based therapeutics, vaccines, and nucleic acid-based therapeutics including applications for bioprocessing (spent cell culture media) and product quality attribute monitoring.
• waters_connect for Small Molecules — Accurate mass-based solutions for screening of small molecules with versatile qualitative and quantitative analysis of compounds like pesticides, drugs of abuse, metabolites, impurities, extractables, and leachables.
• waters_connect for Research & Routine — Accurate mass-based metabolomics, lipidomics and metabolite identification solutions with integration with 3rd Party software (via .mzML and/or via API)

Key Benefits

• Increased lab productivity and throughput with the introduction of support for the Xevo MRT instrument within the Sample Submission and Method Editor applications in a waters_connect workstation install;
• Improved productivity and usability at the point of sample submission with the ability to select injections in the sample list and directly interrogate data in LC-MS Toolkit sessions from either injections being acquired, and from samples acquired completed;
• Increased lab productivity with the introduction of support on waters_connect short term releases for Vion IMS QTof instrument within the UNIFI application for workstation and network installs;
• Improved productivity when submitting samples with Xevo MRT, Xevo G2-XS QTof and ACQUITY RDa by converting acquired data to generic file format (.mzML) in real-time, ensuring immediate availability for third-party software use;
• Increased data clarity and speed to results with data view and interrogation enhancements in the LC-MS Toolkit application via automatic calculation and annotation for the mass resolution of an ion; base peak mass annotations in chromatograms; view and interrogate Xevo MRT data; perform multiple extracted ion chromatograms from pre-saved groups of analytes;
• Increased productivity by generating LC-MS Toolkit sessions in real time and post acquisition at the sample list level from within the submission application;
• Increased usability and productivity for the Small Molecules and Biologics workflows by automating data acquisition in sample submission and data processing in UNIFI when using Xevo MRT, Xevo G3 QTof, Xevo G2-XS QTof, and ACQUITY RDa;
• Faster time to results and enhanced data clarity when using the UNIFI application workflows with Xevo MRT instrument. Benefit from the high mass resolving power and sub-ppm mass accuracy even at the fastest acquisition rates and leverage the power of confident identification of analytes across a range of samples and matrices with the UNIFI Small Molecules and Biologics workflows;
• Improved lab automation and integration with 3rd party software via 17 new endpoints in the waters_connect Application Programming Interface (API). Benefit from a greater API connectivity and performance.

Note: full information on new features and quality improvements available in the release notes

Recommended Use

For customers who:

• want to stay at the forefront of innovation and are comfortable with routinely updating the software to access the latest features and quality improvements.

For customers running the following workflows with the UNIFI application only:

• waters_connect for Biopharma — Accurate mass applications for protein-based therapeutics, vaccines, and nucleic acid-based therapeutics.
• waters_connect for Small Molecules — Accurate mass-based solutions for screening of small molecules with versatile qualitative and quantitative analysis of compounds like pesticides, drugs of abuse, metabolites, impurities, extractables, and leachables.

Key Benefits

• Enhanced compliance readiness with more efficient records handling in draft state and better control policies over signature methods and active multi-user sessions;
• Elevated usability for waters_connect Administration with user interface improvements, such as redesigned icons, optimization of data visible vertically on screen, more visible scrollbars and dynamic zoom adjustments for tabular data;
• Faster analysis method generation in waters_connect UNIFI when handling components with multiple adducts in the detection results section of scientific library. Benefit from the enhanced scientific library import from Excel mechanism for components characterized by multiple adducts;
• Improved data clarity to achieve faster decision making when using the UNIFI Accurate Mass screening workflow for polymers analysis. Benefit from the enhanced isotope clustering algorithm improvements to better resolve typical polymeric isotopic patterns, including those with overlapping isotope clusters;
• Improved productivity when submitting samples by converting acquired data to generic file format in real-time, ensuring immediate availability for third-party software use. The new waters_connect DATA Convert tool enables increased data compatibility with third-party software applications via conversion of MS, MS/MS, DDA and MSE data into mzML format;
• Increased data clarity and faster decision making by interrogating Data Dependent Acquisition (DDA) types and lock mass correcting data in real time in waters_connect LC-MS Toolkit;
• Faster time to results of unknown components with enhanced structural elucidation capabilities in waters_connect LC-MS Toolkit; such as Mass Fragment improvements, including the ability to select alternative structural assignments and report results to PDF;
• New streamlined and efficient waters_connect product ordering and license model to elevate the customer digital software management experience.
• Increased laboratory operational efficiency with waters_connect System Monitoring, enabling users to view real-time status and gain insights from your waters_connect LC-MS instrument fleet as well as LC Empower deployments;
• Enhanced compliance readiness and acquisition workflow usability with .cvs file based data transfer mechanism from your LIMS to waters_connect Sample Submission, including the ability to acquire and process data originated from the LIMS for the waters_connect Quantitation workflow;
• Improved productivity and usability when submitting samples with the ability to view subsequently generated data in real-time via opening waters_connect LC-MS Toolkit at the point of sample injection.

Note: full information on new features and quality improvements available in the release notes

Recommended Use

For customers who:

• want to stay at the forefront of innovation and are comfortable with routinely updating the software to access the latest features and quality improvements.
• want to increase their sample throughput & productivity with an extended number of ACQUITY modules and configurations.

For customers running the following workflows:

• waters_connect for Quantitation — Quantitative analysis software available on our core Xevo tandem quadrupole family of mass spectrometers to enable laboratories to process large sample batches quickly and easily, significantly reducing the time spent on data review. Maximize your productivity for Food and Environmental analytical methodologies.
• waters_connect for Biopharma — Accurate mass applications for protein-based therapeutics, vaccines, and nucleic acid-based therapeutics including applications for bioprocessing (spent cell culture media) and product quality attribute monitoring.
• waters_connect for Small Molecules — Accurate mass-based solutions for screening of small molecules with versatile qualitative and quantitative analysis of compounds like pesticides, drugs of abuse, metabolites, impurities, extractables, and leachables.

Key Benefits

• Improved data clarity to achieve faster decision making when using the UNIFI Accurate Mass screening workflow with Select Series MRT data. Benefit from the enhanced isotope clustering algorithm improvements and leverage  higher spectral resolution data for species containing N15, S34 and O18, and C13 and Cl35;
• Increased lab productivity and throughput with the introduction of support for the ACQUITY PDA Detector and ACQUITY Sample Organizer modules within the Sample Submission and Method Editor applications;
• Increased usability and productivity for accurate mass workflows with the support of Data Dependent Acquisitions (DDA) within the Sample Submission and Method Editor applications when using Xevo G2-XS QTof and Xevo G3 QTof systems;
• Increased usability and reduced waiting time for system readiness with new default instrument systems related settings and faster access to the Instrument System details panel in System Console;
• Increased data clarity and faster decision making by viewing and manipulating 2D PDA in the LC-MS Toolkit application;
• Faster time to results when screening for unknown components with enhanced structural elucidation capabilities in LCMS toolkit;
• Expanded Quantitation workflow capabilities with new MS Quan features to accelerate time to results with focus on PFAS molecules.

Note: full information on new features and quality improvements available in the release notes

Recommended Use

For customers who:

• require a stable, secure and robust solution for a long period of time as frequent upgrades & re-validations have a high cost for their laboratory.

For customers running the following workflows:

• waters_connect for Quantitation — Quantitative analysis software available on our core Xevo tandem quadrupole family of mass spectrometers to enable laboratories to process large sample batches quickly and easily, significantly reducing the time spent on data review. Maximize your productivity for Food and Environmental analytical methodologies.
• waters_connect for Biopharma — Accurate mass applications for protein-based therapeutics, vaccines, and nucleic acid-based therapeutics including applications for bioprocessing (spent cell culture media) and product quality attribute monitoring.
• waters_connect for Small Molecules — Accurate mass-based solutions for screening of small molecules with versatile qualitative and quantitative analysis of compounds like pesticides, drugs of abuse, metabolites, impurities, extractables, and leachables.

Key Benefits

• Elevate your product understanding when using the waters_connect for Quan and the Biologics workflows with the software translation in Japanese;
• Increased compliance readiness with more comprehensive insights in the audit trail for acquisition events and acquisition method;
• Improve your lab productivity and reduce instrument cost of ownership by connecting up to 5 Xevo Tandem Quadrupole instruments in a single network deployment;
• Extend the capabilities of your instrument systems inlet and sources with the support for ACQUITY UPLC M-Class System and NanoLockSpray Ionization Source for Xevo G3 QTof; and multidimensional liquid chromatography with ACQUITY UPLC System with 2D LC Technology for accurate mass workflows within the UNIFI application;
• Improved product robustness and stability when acquiring with the Laboratory Network Device (LND) application reduces data transfer communication bottlenecks caused by instrument errors;
• Increased security with the adoption of Transport Layer Security (TLS) 1.2 for the acquisition workflow when using the Sample Submission and Acquisition Method Editor applications;
• Expanded Biopharma & Quantitation workflow capabilities with new application features to accelerate time to results with focus on RNA and PFAS molecules.

Note: full information on new features and quality improvements available in the release notes

Recommended Use

For customers who:

• want to stay at the forefront of innovation and are comfortable with routinely updating the software to access the latest features and quality improvements.

For customers running the following workflows with the UNIFI application only:

• waters_connect for Biopharma — Accurate mass applications for protein-based therapeutics, vaccines, and nucleic acid-based therapeutics.
• waters_connect for Small Molecules — Accurate mass-based solutions for screening of small molecules with versatile qualitative and quantitative analysis of compounds like pesticides, drugs of abuse, metabolites, impurities, extractables, and leachables.

Key Benefits

• Improved product quality and stability by addressing high impact software anomalies; 
• Improved robustness and performance when importing MassLynx data;
• Increased security with adoption of TLS Transport Layer Security (TLS) 1.2 & Advanced Encryption Standard (AES) encryption algorithm for sensitive data; 
• Increased usability for the waters_connect Accurate Mass workflows with Device Management application, on-click set-up systems on/offline in System Console and dynamic adjustments zoom in/out for tabular data.

Note: full information on new features and quality improvements available in the release notes

Recommended Use

For customers who:

• require a stable, secure and robust solution for a long period of time as frequent upgrades & re-validations have a high cost for their laboratory.

For customers running the following workflows:

• waters_connect for Quantitation — Quantitative analysis software available on our core Xevo tandem quadrupole family of mass spectrometers to enable laboratories to process large sample batches quickly and easily, significantly reducing the time spent on data review. Maximize your productivity for Food and Environmental analytical methodologies.
• waters_connect for Biopharma — Accurate mass applications for prote in-based therapeutics, vaccines, and nucleic acid-based therapeutics including applications for bioprocessing (spent cell culture media) and product quality attribute monitoring.
• waters_connect for Small Molecules — Accurate mass-based solutions for screening of small molecules with versatile qualitative and quantitative analysis of compounds like pesticides, drugs of abuse, metabolites, impurities, extractables, and leachables.

Key Benefits

• Increased lab operational security with support of Windows 10 LTSC 2021 for workstation, LND and Clients PCs;
• Improved data migration tool for a more efficient and secure data migration from UNIFI Software to waters_connect platform;
• Japanese localization for UNIFI application workflows with Xevo G2-XS QTof, Vion IMS QTof, and RDa/BioAccord systems to elevate understanding of product functionalities;
• Improved usability with waters_connect Explorer application for managing records and accessing general properties and information recorded in the audit trail;
• Increased system uptime with platform in-place upgrade mechanism* and simplified product deployment.

Note: full information on new features and quality improvements available in the release notes