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Alliance iS HPLC Systems User Guide
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Alliance iS HPLC Systems User Guide
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Priming the system

Priming the sample manager

Priming the sample manager
Topic LCI-USG-0111, Last Updated 11/21/2025

Priming the sample manager is part of the system startup workflow on the touchscreen and the console.

Priming fills the wash system with wash solvent or the injection pathway with mobile phase. You prime the system to accomplish these tasks:

  • Preparing a new sample manager for operation
  • Preparing a sample manager for operation after it has been idle for more than 24 hours
  • Changing the wash solvent
  • Removing bubbles from the lines

Ensure that the wash solvent is correctly composed, that it is of LC-MS grade, and that it is miscible with other solvents used in the system. Use filters in all solvent reservoirs, and ensure that the volumes of solvents suffice for priming.

To prime the sample manager, run the system startup workflow. See Running the startup workflow.

Notes:
  • You can also prime the seal wash or needle wash by tapping the respective condition card on the system status dashboard.

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To avoid risk of personal injury and to prevent damage to laboratory equipment, always operate your Waters products in accordance with the applicable operational and safety information, your organization’s standard operating procedures, and local regulations.

Refer to the English version of this page for the latest information.

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