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Alliance iS HPLC Systems User Guide
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Alliance iS HPLC Systems User Guide
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Solvent considerations

Solvent viscosity

Solvent viscosity
Topic LCI-USG-0025, Last Updated 11/21/2025

In gradient chromatography, the viscosity changes that occur as the solvents are mixed in varying proportion can affect pressure changes during the run.

In gradient chromatography, the viscosity changes that occur as the solvents are mixed in varying proportion can affect pressure changes during system use.

Although viscosity changes are not generally a consideration when using a single solvent or when under low pressure, if you do not know the extent to which pressure changes affect an analysis at flow rates above 5 mL/min, monitor for pressure exceedance during system use.

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